What Is VDR?

VDR is a gene that encodes for a protein that functions as a receptor for vitamin D, which regulates bone development and calcium absorption. A variant of the gene (rs2228570, FokI polymorphism) is associated with lower bone mineral density in prepubescent girls of white background.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern, as well as the time on-and-off occupancy of the VDRE between the two components. It is also modulated by chromosomal position and binding preferences for specific hormones. Microarray studies of human cells reveal that more than 100 genes have VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual data room (VDR) is an online repository for information and documents pertinent to legal, business, or other proceedings that have restrictions on viewing or downloading. It is accessed via a central computer and an extranet which is a restricted-access Internet connection, allowing users to login at specified times.

VDRs are typically used by investment banks and businesses involved in mergers or acquisitions. They require to communicate information in a clear manner with potential investors and buyers. The due diligence process can also require a large amount of data. Life science companies also use VDRs to store everything from clinical trial results to HIPAA documentation.

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